KMID : 1098420230310030169
|
|
Korean Journal of Medicinal Crop Science 2023 Volume.31 No. 3 p.169 ~ p.179
|
|
Aqueous Extract of Allium victorialis var. Platyphyllum Rhizome Improves Skin Barrier and Suppresses Inflammation
|
|
Koo Hyun-Jung
Kim Sung-Hyeok Ha Chang-Woo Jang So-Hee Choi Jung-Hun Lim Jung-Dae Sohn Eun-Hwa
|
|
Abstract
|
|
|
Background : Atopic dermatitis is a chronic inflammatory skin disease caused by skin barrier dysfunction. Allium victorialis var. platyphyllum (AVP) is a perennial plant considered as a vegetable and herbal medicine. This study aimed to investigate the effects of AVP on skin barrier and inflammatory response and indicate its potential as a new cosmetic materials
Methods and Results : High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ¡¾ 0.02 and 0.10 ¡¾ 0.01 §·/g of chlorogenic and gallic acids, respectively. AVP at 100 §¶/§¢ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 §¶/§¢ and 200 §¶/§¢ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of ¥â-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells.
Conclusions : Therefore, AVP can be developed as a functional cosmetic material for atopy management given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.
|
|
KEYWORD
|
|
Allium victorialis var. platyphyllum, Anti-allergy, Atopic Dermatitis, Anti-inflammatory, Rhizome, Skin Barrier
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|